The novel cryo-to-liquid phase CLEM workflow, which we developed to visualize biological processes in graphene liquid cells, has recently been published in Advanced Functional Materials. The workflow combines light microscopy and cryoTEM to enable the observation of biological processes in nanometer resolution. By vitrifying the sample immediately...
Our custom-made image processing tool for Cryogenic Focused Ion Beam / Scanning Electron Microscopy (Cryo-FIB/SEM) image stacks is now publicly available!3D Cryo-FIB/SEM generates 3D reconstructions of samples by cyclically milling a layer off the vitrified sample and then imaging the newly exposed surface. It combines the advantages of sample...
The Radboudumc Electron Microscopy Center team attended the annual NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek) Biophysics conference on the 7th and 8th of October. The talks covered diverse topics, which were all super informative for the improvement of the facilities' workflows, especially the ElectronMicroscopy parallel session....
The Opening Symposium of the Radboudumc Electron Microscopy Center on January 24 was a success! The event celebrated the completion of our cutting-edge infrastructure and spotlighted the transformative role of electron microscopy in life sciences research.
The work conducted by Robin van der Meijden and colleagues has been recently published in Advanced Functional Materials titled: "A 3D cell-free bone model shows collagen mineralization driven and controlled by the matrix". In this work we demonstrate the strength of combining Raman microscopy with scanning electron microscopy (SEM) to understand...
Today, we successfully completed the installation and launched the operations of our state-of-the-art Talos F200C-G2 TEM microscope. Get ready for an extraordinary imaging experience that allows us to capture biological phenomena in liquid and cryo environments like never before!
Our team developed a creative solution for performing cryogenic correlative light and electron microscopy imaging in 3D samples, recently published in Communications Biology. We have developed a workflow, bridging 3D cryo light microscopy (LM) and 3D cryo FIB-SEM. By imprinting a recognizable and reproducible pattern on the top of high-pressure...
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